Houdini Lab

FCPC Cannabinoid Extract Purification

The cannabis market is maturing and becoming more complex, and as a result, many established corporations are entering the cannabis sector to improve cannabis products by introducing innovative technologies and processing techniques. Rousselet Robatel is bringing to the cannabis extraction industry a great deal more than just a storied past thanks to their combined experience of more than 250 years. Any cannabis producer may now make their own individualized, highly purified botanical extracts thanks to the company’s revolutionary fast centrifugal partition chromatography (FCPC), which makes the process much more straightforward.

In this conversation between Dr. Xynos and Ellis Smith from American Cannabis Company, they discuss the contributions that Kromaton has made to the advancement of the cannabis business through their work with Kromaton.


The Purification Process in Three Steps

Although cannabis extracts have been around for some time, as the cannabis sector evolves, manufacturers are discovering that customers are beginning to expect a higher level of quality from the products they buy. In addition, as the medical applications of specific cannabinoids and other substances found in the plant continue to be validated by the scientific community, there has been an uptick in interest in cannabinoid isolation and the creation of personalized cannabinoid formulations. Rousselet Robatel offers a comprehensive selection of process systems for extraction, enrichment, and purification, including the following:


During the separation process, the Model RC utilizes a centrifugal solid-liquid separation technique that filters the biomass out of the solvent in order to produce an extract while simultaneously lowering the costs associated with its disposal. Following the steps of separation and winterization, the next step is decantation, which is used to separate the crude cannabinoids from other byproducts like as waxes, lipids, and water.

Enrichment consists of performing a centrifugal liquid-liquid solvent extraction and separation after the primary extraction in order to recover the aqueous phase which contains acidic cannabinoids and also recover the solvent phase which contains neutral cannabinoids.

In the final step of the purification process, the Kromaton FCPC is utilized to separate and retrieve individual cannabis components. This method can be altered to extract a wide range of chemicals, such as pure fractions of main and minor cannabinoids, terpenes, alkaloids, flavonoids, and many more. In addition, purification rids the water of pollutants such as pesticides and other chemical, biological, and biologically derived compounds.

Maximum Versatility

The Kromaton is a complete system that can be easily integrated into any business of any size thanks to its adaptability. Rousslet Robatel provides their customers with a comprehensive range of services and standard operating procedures so that they can get their businesses up and running as soon as possible. This is true regardless of whether the client intends to only use the process in a small lab environment for individual compound research or if the producer needs large-scale industrial production.


“FCPC is successful in purifying particular cannabinoids from the mixture in its purest form,” Dr. Xynos noted, “which enables THC removal for entirely THC-free products.”


Applications and Benefits of the System

The capacity to separate certain cannabinoids and chemicals from the plant and/or remove them entirely opens up a wide range of opportunities for cannabis manufacturers. “ In the beginning,” Dr. Xynos noted, “[the industry] was focused more on THC isolation, whether it was from cannabis or even manufactured THC isolate. However, these days, THC-free CBD extracts are in greater demand, not just in hemp but also with medical cannabis.”


Even though the technology of chromatography has been around for some time, Dr. Xynos emphasizes that the operational mode of FCPC chromatography is not the same as that of regular chromatography. In comparison to column, flash, and HPLC chromatography, the Kromaton has a number of benefits, some of which are as follows:


There is not any silica or resin or other solid packing material.

There is no loss of sample due to the irreversible adsorption.

There is no denaturing of any delicate chemicals.

A high capacity for throughput.

Low resource requirements and simple scalability

Cannabinoids and Terpenes as the Primary Focus

With the Kromaton FCPC, any compound can be extracted from its mixture. The Kromaton is able to separate and isolate lipids, sterols, organic and inorganic elements, alkaloids, flavonoids, and even proteins and amino acids from apolar, non-aqueous biphasic systems all the way up to polar, aqueous two-phase systems and everything in between. Cannabinoids are another important component.




Looking Ahead

According to Dr. Xynos, there will be an increased demand for standardized extracts or compounds that have a high level of purity and are of a controlled quality as the cannabis industry becomes more sophisticated and as the pharmacological, food, and botanical extraction industries become more integrated into cannabis. Xynos thinks that the FCPC technology has huge promise in the future of the legal cannabis sector. This belief is based on the company’s anticipation of a developing market for products that target certain cannabinoid concentrations.